September 2025:
We report extreme enrichment of CFI deficiency, an otherwise ultra-rare inborn error of immunity, in the Old Order Amish. This work nearly doubles the number of reported cases of a protean disease that can cause severe neuroinflammatory pathologies. Out now in JACI.
What’s new?
May 2025:
We scoured the ends of the earth for 134 rare PU.1 variants and “raced” them against wild type PU.1. The leaderboard was published in this month’s issue of Blood. (Direct link to paper and commentary by “Mr. B cell” Stu Tangye).
May 2024:
Check out our new work on anti-glycan IgM autoantibodies as contributors to autoimmune disease in CVID patients.
It is out now in JACI!
